Natural selection back in action
One thing that is predictable is that, if the new covid surge is seriously dangerous, some parts of the US will be hit much harder than others. From what I'm seeing around the right-wing blogs and news sites, rejection of anti-covid defenses (vaccines, masks, etc), and denial of the seriousness or even existence of covid, are far more entrenched and militant there now than they ever were during the pandemic. Some examples are here, here, here, here, and here -- that last is a "meme" collection, but many refer to covid defenses. A common view is that the new covid surge is a scam contrived to bring back various restrictions as part of a plot to steal the 2024 election for the Democrats.
Given the deep commitment to such views, it's obvious that the heavily science-denialist parts of the country will almost totally reject whatever precautions the medical establishment finds necessary to combat a new covid surge -- vaccines, masks, lockdowns, or whatever else. Even a substantial rise in the death rate will not dissuade them -- remember, most of these people are convinced that it's the vaccines, not covid, which are killing people (there is an entire fake documentary dedicated to supporting this belief). By contrast, here in left-leaning Portland, masks are already making something of a comeback -- the last couple of times I went out shopping, I saw more people wearing masks than at any previous time in the last year or so, though they are still far from the majority. If the government recommends a return to masks and stores start requiring them, most people here and in other "blue" cities will likely go along. Certainly most will accept the vaccines. And the situation will give workers a major weapon in their battle to resist the bosses' back-to-the-office campaigns.
So, depending on how deadly the new variant is, the stage will be set for another large divergence in death rates between science-denialist and science-accepting parts of the US. There are already huge regional differences in life expectancy:Most of the early-death counties are concentrated in "red" states and regions, while the longest life expectancies are found largely in the "blue" urban areas. If the former reject vaccines and other defenses while the latter embrace them, and if the new variant turns out to be particularly dangerous, we could see the gap in death rates grow monstrously wide. Once again the US will be the scene of a brutal demonstration of natural selection in action.